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胰岛素对脑缺血再灌注损伤的保护作用 被引量：9

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摘要 文章阐述了胰岛素在中枢神经系统的来源,胰岛素在全脑缺血和局灶性脑缺血中的应用及其保护机制,指出胰岛素的应用有望成为缺血性脑血管病的一种治疗方法。
作者 王华梅 李珺 吴家幂
机构地区 安徽省芜湖市皖南医学院弋矶山医院神经内科
出处 《神经疾病与精神卫生》 2006年第1期64-66,共3页 Journal of Neuroscience and Mental Health
关键词 胰岛素 脑缺血 缺血再灌注
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献21

  • 1Auer RN.Insulin,blood glucose levels,and ischemic brain damage[J].Neurology,1998,51(1):39-43.
  • 2王艺东,黎祥喷,洪华,李梅,沈庆煜,邢诒刚,黄如训.胰岛素治疗急性脑梗死的临床研究[J].中国实用内科杂志,2004,24(2):101-102. 被引量：11
  • 3Havrankova J,Roth J,Brownstein MJ.Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels.Studies of obese and streptozotocin-treated rodents[J].J Clin Invest,1979,64(2):636-642.
  • 4Folli F,Ghidella S,Bonfanti L,et al.The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system[J].Mol Neurobiol,1996,13 (2):155-183.
  • 5Schwartz MW,Sipols A,Kahn SE,et al.Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid[J].Am J Physiol,1990,259(3Pt1):E378-E383.
  • 6Banks WA,Jaspan JB,Kastin AJ.Selective,physiological transport of insulin across the blood-brain barrier:novel demonstration by species-specific radioimmunoassays[J].Peptides,1997,18(8):1257-1262.
  • 7Baura GD,Foster DM,Kaiyala K,et al.Insulin transport from plasma into the central nervous system is inhibited by dexamethasone in dogs[J].Diabetes,1996,45(1):86-90.
  • 8Schechter R.Insulin synthesis by isolated rabbit neurons[J].Endocrinology,1988,123:505.
  • 9Voll CL,Auer RN.Insulin attenuates ischemic brain damage independent of its hypoglycemic effect[J].J Cereb Blood Flow Metab,1991,11(6):1006-1014.
  • 10王洪新,马春花,梅元武.胰岛素对大鼠局灶性脑缺血再灌注损伤的保护作用[J].卒中与神经疾病,2004,11(4):220-222. 被引量：3

二级参考文献27

  • 1Voll CL, Auer RN. Insulin attenuates ischemic brain damage independent of its hypoglycemic effect. J Cereb Blood Flow Metab, 1991, 11(6): 1006-1014.
  • 2Zea Long EL, Weinstein PR, Canson S, et al. Reversible middle cerebral artery occlusion without Craniotomy in rats. Stroke, 1989,20(1): 84-91.
  • 3Havrankova J, Roth J, Brown-stein MJ. Con centrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and strap zotoc in-treated rodents. J Clin Invest, 1979, 64(2) :636-642.
  • 4Folli F, Ghidella S, Bonfantil, L, et al. The early intra cellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammlian Malian central nervous system. Mol Neurobiol, 1996, 13(2):135-183.
  • 5Schwart ZMW, Sipols A, Kahn SE, et al. Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid. Am J Physiol,1998, 259(3 PTI) :E3378-E3383.
  • 6Voll CL, Auer RN. Insulin attenuates ischemic brain damageindependent of its hypoglycemic effect. J Cereb Blood Flow Metab, 1991, 11(6): 1006-1014.
  • 7White BC, Grossman LI, O' neil BJ, et al. Global brain ischemia and reperfusion. Ann Emery Med, 1996, 27(5):588-594.
  • 8Garcia de Lacoba M, Alarcon C, Dela Rosa EF, et al. Insulin/insulin-like growth factor I hybrid receptor's with high affinity for insulin are developmentally regulated during neurogenesis. Endocrinology, 1999, 140(1):233-243.
  • 9[3]Zea Longa EL, weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke,1989,20:84.
  • 10[4]Zhu CZ, Auer RN. Intraventricular administration of insulin and IGF-1 in transient forebrain ischemia[J]. J Cereh Blood Flow Metab, 1994,14:237.

共引文献20

同被引文献77

引证文献9

二级引证文献18

神经疾病与精神卫生
2006年 第1期

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