血清B型利钠肽水平对小儿呼吸困难的诊断价值

The evaluation of B-type natriuretic peptide in differentiating cardiac dyspnea from lung diseases in children

目的：探讨血清B型利钠肽（B-type natfiuretie peptide，BNP）浓度对判断小儿呼吸困难应用价值。方法：用ELISA法检测有呼吸困难症状的心衰24例、肺炎23例、肺炎心衰18例、正常对照15名、肺炎心衰恢复期10例患儿的血清BNP浓度。结果：心衰组BNP浓度（141．55±75．99）ps／ml高于肺炎心衰组（113．73±87．05）pg／ml、肺炎组（26．00±14．57）pg／ml及正常组（19．31±10．29）pg／ml（P〈0．05-P〈0．01）；肺炎心衰组显著高于肺炎组及正常组（P〈0．01），肺炎组与正常组比较差异无显著性（P〉0．05）。结论：检测血清B型利钠肽浓度对判断小儿心功能状态有一定参考价值。

Objective：To observe the value of B-type natriuretic peptide （BNP） in differentiating cardiac dyspnea from lung diseases in children. Methods：The concentrations of BNP in 24 children with congestive heart failure（CHF） ,23 with pneumonia, 18 with CHF combined with pneumonia and 15 healthy children were measured with BNP ELISA KIT. Results：The BNP level of the patients with CHF was （ 141.55±75.99） pg/ml, which was significantly higher than that of patients with pneumonia （ 26.00±14.57 ） pg/ml （ P 〈 0.01 ） and higher than that of patients with CHF combined with pneumonia （ 113.73±87.05 ） pg/ml （ P 〈 0.01 ）, and higher than that of healthy children（ 19.31±10.29）pg/ml（ P 〈 0.01 ）. The BNP level of the patients with CHF combined with pneumonia was significantly higher than that of patients with pneumonia and that of healthy children（ P 〈 0.01 ）. The BNP level was not significantly different between the latter two groups （ P 〉 0.05 ）. Conclusions： It suggests that the level of BNP is of value in determining the cardiac function of children with pneumonia.