西藏地产藏药大叶秦艽的抗溃疡病作用研究

The Anti-ulcer Effect of Tibet Medicine of Gentiana macrophylla

目的观察西藏地产藏药大叶秦艽的抗溃疡病作用,同时研究其初步作用机理。方法采用预防性给药,观察大叶秦艽乙醇提取物(石油醚脱脂)组分对阿司匹林诱导大鼠胃溃疡模型及无水乙醇诱导大鼠胃粘膜损伤胃溃疡模型的作用。结果西藏地产藏药大叶秦艽乙醇提取物(石油醚脱脂)组分能明显缩小阿司匹林及乙醇诱导大鼠胃溃疡模型的溃疡面积,大剂量有减少胃液总量作用和胃蛋白总量分泌作用,与对照组相比有显著性差异。结论该提取物有预防溃疡病作用,其机理有待进一步研究。

Objective To study the anti-ulceration effect of Centiana rnacrophylla from Tibet,and the mechanism of action. Methods We studied the effect of the Gentiana macrophylla ethanol extract on aspirin and absolute ethylalcohol-induced rat gastric ulcer models. Results The results showed that the Gentiana macrophylla ethanol extract could significantly dwindle the areas of the gastric ulcer models. It could reduce the total quantity of gastric juice and the secrte of gastric protein if the quantity of Gentiana macrophylla ethanol extract were enough. There was no difference between them and control. Conclusion The Gentiana macrophylla ethanol extract could prevent gastric ulcer and the mechanism need further research.