还原型谷胱甘肽合复方丹参针治疗酒精性肝病

Treating 41 Cases of Alcoholic Liver Disease with Reduced Glutathione Combined with Fufangdanshen

目的:研究还原型谷胱甘肽联合复方丹参注射液治疗酒精性肝病临床疗效。方法:选择酒精性肝病住院及门诊患者82例,随机分治疗和对照两组,各41例。两组均常规给予门冬氨酸钾镁、维生素类及氨基酸等药物治疗,并严格禁酒。治疗组在此基础上给予还原型谷胱甘肽联合复方丹参注射液治疗,疗程1个月,观察患者症状改善,肝功能指标及影像学变化情况。结果:治疗组总有效率97.6%,对照组63.4%,两组比较,P<0.01;治疗组显效疗程10.6天,明显少于对照组的22.6天,P<0.01。1个疗程结束后,治疗组ALT、AST、GGT、TG、TC下降幅度明显高于对照组,P均<0.01;治疗组ALT、AST、GGT、TG、TC复常率分别为95.1%、90.2%、85.4%、82.9%和80.5%,与对照组比较,P均<0.01。结论:还原型谷胱甘肽联合复方丹参注射液治疗酒精性肝病疗效较好,值得临床推广应用。

Objective：To explore the clinical curative effect of reduced glutathione combined with Fufangdanshen on treating alcoholic liver disease（ALD）. Methods：82 cases with ALD from hospitalization and outpatients were randomly divided into the treatment group and the control group （41 cases,respectively）. Both groups were treated by the regular western medicine such as potassium magnesium aspartate, vitamin and amino acid ,with temperance severely. Additionally, the treatment group was treated by reduced glutathione combined with Fufangdanshen, with a therapy course of 1 month. The improvement of clinical syndrome, liver function indexes and video variation. Results： The total effective rates of the treatment group and the control group were 97.6% and 63.4% respectively and there was significant difference between two groups （ P 〈 0.01 ）. The times brought significant effect cost 10.6 days averagely in the treatment group,which was less obviously than that in contrast group （ P 〈 0.01 ） The fan extents of ALT, AST, GGT,TG and T-CH in the treatment group were higher than those in the contrast group （ P 〈 0.01 ）. The comeback rates of ALT, AST, GGT, TG and T-CH were 95.1%, 90.2%, 85.4% ,82.9% and 80.5%, which had significant difference from the contrast group （ P 〈 0.01 ）. Conclusion： Reduced glutathione combined with Fufangdanshen have better curative effect on ALD, which is worth applying in the clinics.