摘要
目的:观察低剂量十一酸睾酮(TU)对心肌梗死后慢性心力衰竭(HF)雄性大鼠血清白介素-10(IL-10)水平的影响。方法:对120只健康雄性SD大鼠随机行冠状动脉结扎(n=105)或假手术(PS,n=15)。6周后将存活的44只模型鼠随机分为2组:心力衰竭+TU治疗组(HF+TU组,n=22)给予TU 5 mg/kg.2周肌肉注射;心力衰竭组(HF组,n=22),给予安慰剂。用药12周后测定血清睾酮(T)及IL-10浓度。结果:HF组雄鼠血清T水平明显低于PS组(153.91±77.45 vs 475.28±161.37 ng/d1,P<0.05),HF+TU组T浓度与PS组无显著性差异(415.50±59.22 vs 475.28±161.37 ng/dl,P>0.05)。HF组较PS组血清IL-10浓度明显下降(4.90±1.32 vs 7.30±2.14 pg/ml,P<0.05)。HF+TU组较HF组血清IL-10浓度显著升高(6.55±2.11 vs4.90±1.32 pg/m1,P<0.05)。HF+TU组与PS组血清IL-10浓度无显著性差异(6.55±2.11 vs 7.30±2.14 pg/m1,P>0.05)。结论:低剂量睾酮可提高心肌梗死后慢性心衰雄性大鼠血清IL-10水平。
Objective： To investigate the effect of low dose testosterone undecanonate（TU） on serum interleukin-10（IL-10） level in male rats postinfarction heart failure（HF）model. Methods： 120 SD male rats were randomly assigned to ligation of coronary artery（ n = 105） or pseudo operation （PS, n = 15）. 6 weeks later, 44 survived model rats were randomly divided into 2 groups： HF ＋ TU group（n = 15） treated with TU 5 mg/kg per 2 weeks intramuscular injection; HF group（ n = 22） treated with placebo. Serumtestosterone （T） and IL-10 level were determined after treatmemt for 12 weeks. Results： Serum testosterone level in HF group were significantly lower than which in the PS group（153.914 ± 77.45 vs. 475.284 ± 161.37 ng/dl, P 〈 0.05）, serum testosterone level in HF ＋ TU group had no significant change compared with that in PS group（415.504 ± 59.22 vs. 475.28 ± 161.37 ng/dl, P 〉 0.05）. Serum IL-10 was significantly lower （4.904 ± 1.32 compared with that in PS group; After TU therapy, vs.7.30 ± 2.14 pg/ml, P 〈 0.05） in HF group serum IL-10 level increased markedly （6.554±2.11 vs. 4.904±1.32 pg/ml, P 〈 0.05）. No significant change was found of serum IL-10 level in HF＋ TU groupaccording to that in PS group（6.55 ± 2.11 vs. 7.304 ± 2.14 pg/ml, P 〉 0.05）. Conclusion ： Low dose testosterone induced an increase in IL-10 in male rats postinfarction HF model.
出处
《河南医学研究》
CAS
2006年第1期26-28,共3页
Henan Medical Research
基金
河南省普通攻关资助项目(0324410132)
