社区新发精神分裂症危险因素研究

A study of risk factors in new cases of schizophrenia in community

对城乡社区47万人群5年中204例新发精神分裂症患者的发病危险因素进行了1：2病例对照研究。结果发现，精神分裂症的发病与阳性家族史、家庭和睦程度、生活事件、社会情感和经济支持、家庭结构类型和婚姻状况等诸多因素有关。1：2配对Logistic多元逐步回归分析进一步揭示：生物学因素是精神分裂症发病的主要危险因素，社会心理因素是重要的促发因素。

Objective: To study risk factors in new cases of schizophrenia in the community. Method: This isa prospective controlled study of 204 new cases of schizophrenia out of a population of 470, 000 within 5years. Results: 1: 2 ratio logistic multiple stepwise analysis showed that onset of schizophrenia was re-lated to positive family history, family disharmony, life events, soical and economic support and maritalstatus, among others. Discussion: Biological factors are the main risk factors of schizophrenia, whilepsychosocial factors are precipitating factors.