高血压患者颈动脉内中膜厚度与血清胆红素相关性研究

Relationship between serum bilirubin and carotid atherosclerosis in patients with hypertention

目的探讨原发性高血压(EH)患者颈动脉内中膜厚度与血清胆红素的关系。方法对141例EH患者行颈动脉超声多普勒检查,根据颈动脉粥样硬化程度(狭窄)程度分为5组,同时检测血清胆红素水平。结果5组血清胆红素值分别为:内膜增厚组(12.5±3.0)μmol/L;内膜斑块形成组(10.3±2.6)μmol/L;管腔轻度狭窄组(8.8±1.6)μmol/L;管腔中度狭窄组(7.0±1.1)μmol/L;管腔重度狭窄组(6.3±1.0)μmol/L。5组间比较差异均有统计学意义(P<0.05或P<0.01)。血清胆红素浓度与动脉粥样硬化程度呈负相关。结论低血清胆红素浓度可作为动脉粥样硬化危险因素的指标之一。

Objective To evaluate the relationship between serum bilirubin and carotid atherosclerosis in patients with hypertention. Methods One hundred and forty - one patients were examined by color Doppler ultrasonography to detect carotid atherosclerosis and in the mean time, the serum bilirubin was measured. These patients were divided into five groups according to the degree of carotid atherosclerosis. The relationship between the varying degrees of carotid atherosclerotic with serum total bilirubin concentration were assessed,and all the data were underwent statistical analysis. Results The serum total bilirubin levels：carotid intima thickened group（ 12.5 ± 3.0 ） μmol/L; carotid atheromatous plaques group （ 10.3 ± 2.6 ） μmol/L; minor stenosis group（8.8 ± 1.6）μmol/L; middle stenosis group （7.0 ± 1. 1 ） μmol/L; high - grade stenosis group （6.3± 1.0） μmol,/L. There were significant differences among them （ P 〈0.05 or P 〈0.01 ）. There was negative relativity between the serum bilirubin and the incidence of carotid atherosclerosis. Conclusion The lower concentration of bilirubin was probably one of the risk factors of carotid atherosclerosis.