黄芪改善心血管功能的作用

Effects of radix astragali in ameliorating cardiovascular function

目的:观察黄芪对心血管疾病患者的临床作用,为该药材在临床上的正确使用提供科学根据。方法:实验于2003-06/2004-12进行。观察对象为居住在锦州市的解放军干部休养所离、退休的军人,锦州市高校教师,锦州市的干部、工人、居民等。按中华医学会老年医学分会制定的老年心血管疾病患者诊断标准确定诊断共纳入心血管疾病者54例,患者口服黄芪(将药材用蒸馏水洗净、烘干,进行粉碎,然后将细末过筛并装入胶囊内以备口服),每人服用黄芪的剂量是50g/d,分3次口服,服用3个月为1个疗程。服药3个疗程后观察患者临床衰老指标、临床表现、心电图和心阻抗图及生化指标、血液流变学等一系列项目的变化。结果:54例患者均进入结果分析,无脱落者。①患者服药后的临床症状的变化:54例患者服药后,临床症状全部消失的有4例(7%),有所改变的为36例(67%),无变化者14例(26%),总有效率74%。②患者服药后的心电图和心阻抗图的变化:患者用药后,其窦性心动过缓无效1例,增快2例,房早和室早无效1例,消失4例;心肌缺血无效3例,改善22例。用药后的每搏量、心搏指数、心输出量、心脏指数比用药前升高(P<0.05),射血前期/左室射血时间比用药前降低(P<0.05)。③患者服药后的血脂和血液流变学的变化:患者用药后的血清三酰甘油、高密度脂蛋白胆固醇比用药前升高,胆固醇、低密度脂蛋白胆固醇比用药前降低;用药后的红细胞沉降率、血细胞比容比用药前升高,全血比黏度、全血比黏度1/红细胞比积、血浆比黏度则比用药前降低。结论:黄芪是一种比较好的延缓衰老及治疗心血管疾病的中草药,值得在临床医疗实践中推广使用。

AIM： To observe the clinical effect of radix astragali on patients with cardiovascular disease so as to provide scientific basis for correct clinical application. METHODS： The experiment was conducted from June 2003 to December 2004. Retired military soldiers of Entertainment Center of Chinese PLA living in Jinzhou, teachers in universities of Jinzhou as well as cadres, workers and residents of Jinzhou were took as observation objects. According to the diagnosis standard of elderly people with cardiovascular disease made by Geronotology Branches of Chinese Medical Association, 54 patients with cardiovascular disease were selected. Patients all orally took radix astragali at the dose of 50 g/d three times a day with one month as a progress （Materials were washed with distilled water, and then dried and crashed into powder, which was sifted and put into the capsules for patients to take orally）. Changes of clinical aging index, clinical expression, electrocardiogram, impedance cardiogram, biochemical indicator, blood rheology etc. in patients were observed three progresses after the administration. RESULTS： Totally 54 patients were involved in the analysis of results, and no subject withdrew from the experiment. ①Changes of clinical symptoms in patients after drug-taken： Of 54 patients who had taken drugs, clinical symptoms of 4 patients （7%） disappeared and that in 36 patients （67%） changed to some degree, 14 patients （26%） without changes, the total efficient rate was 74.1%.②Changes of electrocardiogram and impedance cardiogram of patients after drug-taken： After the administration, there were 1 patient with inefficient sinus bradycardia, 2 patients with acceleration, 1 patients with atrial premature beat and ventficular premature beat and 4 patients with syptoms disappeared; Three patients with inefficient myocardial ischemia, 22 patients with amelioration. The stroke volum （SV）, stroke index （SI）, cardiac output （CO） and cardiac index （CI） in patients after ad- ministration were increased than those before administration （P 〈 0,05） and the pre-ejection/left ventricular ejection time （PEP/LVET） were lower than those before administration （P 〈0.05）.③Changes of blood lipid and blood rheology in patients after administration： The serum triacylglycerol, high-density lipoproteins cholesterol （HDL-CH） after administration were higher than those before administration; Cholesterin （Ch） and low-density lipoprtein （LDL） were lower than those before adminstration; The bolld sedimentation rate （BSR） and hematocrit （HMT） after administration were higher than those before administration, while the whole blood specific viscosity l/hematocrit and.the serum specific viscosity were lower than those before administration. CONCLUSION： Radix astragali is a better herb medicine in delaying insenescence as well as treating cardiovascular disease, which is worthy to be spreaded and applicated in the clinical treatment practice.