胚胎植入障碍与先兆子痫

Abnormal Implantation and Pathogenesis of Pre-eclampsia

先兆子痫是妇产科临床上造成孕产妇和围产儿死亡的主要原因之一,但由于病因学尚未得到阐明,它仍被称为一种“理论性疾病”。如何有效地预测、诊断、治疗和预防先兆子痫,一直是全世界生殖医学界倍加关注的问题。越来越多的证据表明胚胎植入障碍与先兆子痫的发生直接相关,因而探讨生理和病理状况下滋养层细胞与母体子宫之间的对话机理可能成为阐明先兆子痫发病机理的重要突破口。

Pre-eclampsia （PE） has been one of the serious problems that are life-threatening to both pregnant women and their fetuses. PE is still a so-called disease of theories as its pathogenesis remains unclear, and there has been little progress in the prediction, diagnosis, treatment and prevention of PE. Increasing evidence has indicated that abnormalities in embryonic implantation contribute to the occurrence of PE. Therefore, understanding the molecular mechanisms underlying physiological and pathological crosstalk between placental trophoblasts and maternal uterus may lead to a critical breakthrough in the elucidation of PE etiology.