摘要
Daxx(death dom ain assoc iated prote in)是一种多功能的核蛋白,能与Fas死亡结构域结合,激活Jun氨基端激酶通路诱导细胞凋亡。Daxx也具有抗凋亡作用。Daxx与细胞内的转录因子和转录相关蛋白结合,发挥转录调控的作用。Daxx与多种病毒蛋白相互作用,调节病毒的复制周期和感染性。
As a multifunctional nuclear protein, Daxx can activate the Jun N-terminal kinase （JNK） pathway by binding to Fas death domain. volved in the transcriptional control by interacting proteins. In addition, Daxx is able to regulate Daxx also has anti-apoptosis capacity and is inwith several transcriptional factors and associated the viral infection cycles and infectivity through its interaction with some viral proteins. The article reviews the latest advances in the study of Daxx on pro-/anti-apoptosis, transcriptional regulation and interaction with viral proteins.
出处
《医学分子生物学杂志》
CAS
CSCD
2006年第2期139-142,共4页
Journal of Medical Molecular Biology
基金
湖南省教育厅资助项目(No.02C391)~~
关键词
Daxx蛋白
细胞凋亡
转录调控
Tdeath domain associated protein
cell apoptosis
transcriptional regulation
