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NKT细胞及其免疫调节与免疫耐受诱导作用 被引量：2

(NKT Cells and Their Immunoregulation and Immunotolerance Induction)
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摘要 NKT细胞是一种特殊类型的T淋巴细胞,同时表达NK细胞和T淋巴细胞标记,其主要特征为T细胞受体基因表达的恒定性、CD1d的限制性以及细胞因子产生的高水平性。NKT细胞通过识别由非经典的MHC-Ⅰ类分子CD1d递呈的糖脂类抗原而活化,通过分泌大量Th1和Th2类细胞因子,调节Th1和Th2淋巴细胞的分化,参与自身免疫、感染免疫、抗肿瘤免疫和移植免疫等多种免疫反应。 NKT cells are a unique lymphocyte sublineage. In contrast to both conventional T lymphocytes and natural killer ceils, NKT ceils are reactive to the non-classical MHC-Ⅰ antigen-presenting molecule CDld, and they recognize glycolipid antigens rather than peptides. Moreover, by promoting the secretion of Thl or Th2 cytokines, they play up-or down-regulating roles in a variety of diseases, including autoimmune diseases, infectious diseases, cancer and transplantation.
作者 陈勇 陈杰 龚建平
机构地区 重庆医科大学附属第二医院肝胆外科
出处 《医学分子生物学杂志》 CAS CSCD 2006年第2期143-145,共3页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No.30500473 No.30471696)~~
关键词 NKT细胞 CD1d限制性 细胞因子 免疫调节 免疫耐受 NKT cell CD1d-dependence cytokine immune regulation immune tolerance
分类号 R392.12 [医药卫生—免疫学]
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参考文献23

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同被引文献9

  • 1陈杰,陈勇,龚建平.NKT细胞及其免疫功能[J].山西医科大学学报,2006,37(5):552-554. 被引量：2
  • 2杨洁,范华骅,聂晓绚,高砾,刘嬿,章平,高峰.人外周血Vα24 NKT细胞和CD3^+CD56^+CIK细胞生物学特性的比较研究[J].中国输血杂志,2006,19(5):356-360. 被引量：8
  • 3Fischer K, Kawano T, CU I J, et al. Mycobacterial Phosphatidy Linositol Mannoside Is a Natural Antigen for CD1d-restricted T Cells [ J]. Proc Nat Acad Sci USA, 2004,101 (2) : 10685-10690.
  • 4Nicol A, Nieda M, Koezuka Y, et al. Human Invariant V Alpha-24^+ Natural Killer Cells Activated by Alpha- Galactosylceramide (KRN7000) Have Cytoxicanti-tumour Activity Through Mechanisms Distinct from T Cells and Natural Killer Cells [ J ]. J Immunology, 2000,99 ( 2 ) : 229-234.
  • 5Bruix J, Barrera J M, Galvet X, et al. Prevalence of Antibodies to Hepatitis C Virus in Spanish Patients with Hepatocellnar Carcnoma and Hapatic Cirrhosis [ J ]. Lancet, 1989,2 ( 5 ) : 1004-1016.
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  • 8Kalami K, Lane T E, Chisari F V, et al. Cutting Edge: Inhibition of Hepatitis B Virus Replication by Activated NKT Cells Does not Require Inflammatory Cell Recruitment to the Liver[ J ]. J Immunol,2001,167 (12) :6701- 6711.
  • 9陈佩杰.运动免疫学研究进展[J].体育科学,2000,20(6):41-46. 被引量：86

引证文献2

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医学分子生物学杂志
2006年 第2期

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