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microRNA与血液系统肿瘤的研究进展 被引量：1

Progress in Research on microRNA and Hematological Malignancies
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摘要 微小RNA(m icroRNAs,m iRNAs)是一类22个核苷酸左右的非编码调控RNAs,它可以通过切割mRNA或者是抑制翻译两种机制,在转录后水平发挥调控动植物生长发育的重要作用。最近,大量有关文献证实,哺乳动物中m iRNAs可能调控了大量的靶基因,从而影响多种生物学功能。许多从小鼠骨髓细胞中克隆而来的m iRNAs,在各种造血细胞系中受到不同的调控,而其中一些m iRNAs与白血病等造血系统恶性肿瘤有关。 microRNAs （miRNAs） are class of 22 nucleotide non-coding regulatory RNAs, which plays important regulatory roles in animal and plant development at the post-transcriptional level. Such functions are conducted either through mRNA cleavage or translational repression. Recently plenty of papers demonstrated that miRNAs in mammals may control a surprisingly wide variety of genes, thus impacting many aspects of biology. Many miRNAs cloned from mouse bone marrow cells are differentially regulated in various hematopoietic lineages, and some of them are linked to hematological malignancies （e. g. Leukemia）. This review discusses the recent advances in research on miRNAs and hematological malignancies.
作者 周珏宇 马文丽 郑文岭
机构地区 南方医科大学基因工程研究所 华南基因组研究中心
出处 《医学分子生物学杂志》 CAS CSCD 2006年第2期156-158,162,共4页 Journal of Medical Molecular Biology
关键词 微小RNA 小干扰RNA 白血病 miRNA siRNA leukemia
分类号 Q522 [生物学—生物化学] R733 [医药卫生—肿瘤]
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参考文献20

  • 1[1]BARTEL D P.MicroRNAs:Genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
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同被引文献19

  • 1廖荣霞,孙建国,陈正堂,周建新.小鼠肝脏特异的微RNA真核表达载体的构建及鉴定[J].重庆医学,2004,33(7):965-967. 被引量：8
  • 2李招权,魏明竟.微RNA在肿瘤研究中的意义[J].重庆医学,2006,35(19):1803-1806. 被引量：5
  • 3O'Donnell KA, Wentzel EA, Zeller KI, et al. c Mye-regulated microRNAs modulate E2F1 expression [J].Nature, 2005,4(7043) :839.
  • 4Stark A, Brennecke J, Bushati N, et al. Animal microRNAs contribute to gene expression and have a significant impact on 3'UTR evolution[J].Cell, 2005,123(6):1133.
  • 5Berezikov E,Cuppen E, Plasterk RH, Approaches to microRNA discovery[J]. Nature Genet, 2006,38 : 2.
  • 6Chen CZ, Li L, Lodish HF, et al. MicroRNAs modulate hematopoietic lineage differentitation [J].Science, 2004, 303:83.
  • 7Rogaev El. Small RNAs in human brain development and disorders[J]. Biochemistry, 2005,70(12) : 1404.
  • 8Clop A,Marcq F,Takeda H,et al. A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep[J]. Nature Genet, 2006,38(7) :813.
  • 9Chen JF,Mandel EM,Thomson JM,et al. The role of mi croRNA-1 and microRNA-133 in skeletal muscle prolifer ation and differentiation [J]. Nature Genet, 2006,38 ( 2 ) 228.
  • 10Chen CZ. MicroRNAs as oncogenes and tumor suppressors[J]. N Engl J Med,2005,353(17) : 1768.

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医学分子生物学杂志
2006年 第2期

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