多官能团分枝状化合物的合成研究Ⅲ　四方向、六方向醚－酰胺键型分枝状化合物的合成

Studies on the Synthesis of Multifunctional Groups and Multibranched Compounds Ⅲ. Synthesis of Four and Six-Directional Ether-Amide Bond Branched Compounds

本文报道四方向及六方向醚－酰胺键型多官能团分枝状大分子的合成。目标化合物以２，４－二羟甲基－１，５－戊二醇及肌醇分别为四方向及六方向起始核心，以从季碳原子三倍对称分散的化合物（１）或（３）为三分支侧链。通过醚键进行空间延伸，以酰胺键进行分枝连接，经过一取代，所合成的分枝状化合物的末端官能团数是原起始核心的三倍。它们的合成可望为新型药物的合成提供工具化合物。

The syntheses of the four and six-directional ether-amide bond branched macromolecules utilizing 2, 4-dihydroxymethyl-1, 5-pentadiol and inositol as four and six-directional initiator cores were described. The dendrimer syntheses utilized three branched monomers(1) or (3),possessing 3-fold symmetry and branches emanating from a tetrahedral carbon branch point, as the key building block. The title compounds were respectively synthesized with three branched building blocks via amido linkage procedure. In just one generation, the number of the functionalities in the exterior layer of the muitibranched compounds are thrice those initiator cores. We look forward to providing tool s compounds for syntheses:of new type of drugs.