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盘基网柄菌柄细胞分化过程中gp150分子的作用 被引量:2

Function of gp150 in the Differentiation of Stalk Cell during Dityosteliun Discoideum Development
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摘要 饥饿的盘基网柄菌进入多细胞发育期后,在细胞疏松结合阶段,gp150分子分布在多细胞体外周;在蛞蝓体阶段,gp150分子把蛞蝓体分成前孢子细胞区和前柄细胞区两个部分,在分化成柄细胞的区域内gp150分子的量逐渐增多.实验结果表明gp150分子与柄细胞分化有密切关系. Cells of Dictyostelium discoideum are trigged to undergo development when they are depleted their food source. Cell adhesion molecules play an important role in maintaining the integrity of cell aggregation and influencing subsequent cell-type differentiation and cell sorting. At the loose aggregation stage , gp150 was localized on the peripheral area of multicellular aggregation. At the slug stage, the prespore cell domain and prestalk cell domain were separated by the gp150 molecule, quantity of the gp150 molecule become to increase in the pretalk cell domain following Dictyostelium discoideum development. Thus the temporal of gp150 molecule expression and the special localization of gp150 molecule are related with the differentiation of stalk cells Di ctyostelium discoideum development.
作者 侯连生
出处 《华东师范大学学报(自然科学版)》 CAS CSCD 北大核心 2006年第2期63-67,共5页 Journal of East China Normal University(Natural Science)
基金 国家自然科学基金(30490200)
关键词 盘基网柄菌 柄细胞 发育 分化 gp150 Dictyostelium discoideum stalk cell development differentiation gp150
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参考文献19

  • 1Knecht D A,Fuller D L,Loomis W F.Surface glycoprotein,gp24,involved in early adhesion of Dictyostelium discoideum[J].Dev Biol,1987,121:277~283.
  • 2Brar S K,Siu C-H.Characterization of the cell adhesion molecule gp24 in Dictyostelium discoideum [J].J Biol Chem,1993,268:24 902~24 909.
  • 3Wong E F S,Brar S K,Sesaki H,et al.Molecular cloning and characterization of DdCAD-1,A Ca^2+-dependent cell-cell adhesion molecule in Dictyostelium discoideum[J].J Biol Chem,1996,271:246~249.
  • 4Fontana D R.Two distinct adhesion systems are responsible for EDTA-sensitive adhesion in Dictyostelium discoideum [J].Differwentiation,1993,53:139~ 147.
  • 5Beug H,Katz F,Gerisch G.Dynamics of antigenic membrane sites relation to cell aggregation in Dictyostelium discoideum[J].J Cell Biol,1973,56:647~658.
  • 6Muller K,Gerisch G.A specific glycoprotein as the target site of adhesion blocking Fab in aggregating Dictyostelium cells[J].Nature,1978,274:445~449.
  • 7Siu C-H,Lam T Y,Choi A H C.Inhibition of cell-cell binding at the aggregation stage of Dictyostelium by monoclonal antibodies directed against the contact a glycoprotein[J].J Mol Biol,1985,116:469~488.
  • 8Geltosky J E,Weseman J,Bakke A,et al.Identification of a cell surface glycoprotein involved in cell aggregation in Dictyostelium discoideum[J].Cell,1979,18:391~398.
  • 9Gao E N,Shir P,Siu C-H.Purification and partial characterization of a cell adhesion molecule(gp150) involved in postaggregation stage cell-cell binding in Dictyostelium discoideum[J].J Biol Chem,1992,267:9 409~9 415.
  • 10侯连生.gp150蛋白在盘基网柄菌发育中的作用及粘附分子间关系的分析[J].动物学报,2004,50(1):75-82. 被引量:14

二级参考文献52

  • 1[1]Aubry L, Firtel R, 1999. Integration of signaling networks that regulate Dicteostylium differentiation. Annu. Rev. Cell Dev. Biol.15: 469- 517.
  • 2[2]Beug H, Katz F, Gerisch G, 1973. Dynamics of antigenic membrane sites relation to cell aggregation in Dictyostelium discoideum. J.Cell Biol. 56: 647 - 658.
  • 3[3]Brat SK, Siu CH, 1993. Characterization of the cell adhesion molecule gp24 in Dictyostelium discoideum. J. Biol. Chem. 268: 24 902 -24 909.
  • 4[4]Burridge K, Chrzanoska-Wodnika M, 1996. Focal adhesion, contractility, and signaling. Annu. Rev. Cell Dev. Biol. 12: 463-519.
  • 5[5]Coates JC, Harwood AJ, 2001. Cell-cell adhesion and signal transduction during Dictyostelium development. J. Cell Sci. 114:4 349-4 358.
  • 6[6]Desbarats L, Brar SK, Siu CH, 1994. Involvement of cell-cell adhesion in the expression of the cell cohesion molecule gp80 in Dictyostelium discoideum. J. Cell Sci. 107: 1 705 - 1 712.
  • 7[7]Dynes JL, Clark AM, Shaulsky G, Kuspa A, Loomis WF, Firtel RA,1994. LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium. Genes Dev. 8:948 -958.
  • 8[8]Fontana DR, 1993. Two distinct adhesion systems are responsible for EDTA-sensitive adhesion in Dictyostelium discoideum. Differentiation 53: 139- 147.
  • 9[9]Fontana DR, 1995. Dictyostelium discoideum cohesion and adhesion.In: Richardson PD, Steiners M, ed. The Principles of Cell Adhesion. Boca Ration, FL: CRC Press, 63-86.
  • 10[10]Gao EN, Shir P, Siu CH, 1992. Purification and partial characterization of a cell adhesion molecule (gp150) involved in postaggre gation stage cell-cell binding in Dictyostelium discoideum. J. Biol Chem. 267: 9409-9415.

共引文献14

同被引文献49

  • 1彭建涛,施佳乐,谭宁,侯连生.盘基网柄菌中分化诱导因子信号与细胞命运决定[J].细胞生物学杂志,2006,28(2):183-187. 被引量:2
  • 2谭宁,施佳乐,彭建涛,侯连生.盘基网柄菌细胞分化和凋亡的形态特征[J].动物学报,2006,52(3):603-611. 被引量:7
  • 3Wang J, Hou L, Awrey D, Loomis WF, Firtel RA, Siu CH. The membrane glycoprotein gpl50 is encoded by the lagC gene and mediates cell-ceU adhesion by heterophilic binding during Dic- tyostelium development. Dev Biol 2000; 227(2): 734-45.
  • 4Mutzel R, Lacombe ML, Simon MN, Gunzburg JD, Veron M. Cloning and cDNA sequence of the regulatory subunit of cAMP- dependent protein kinase from Dictyostelium discoideum. Proc Natl Acad Sci USA 1987; 84(1): 6-10.
  • 5Mann SK, Richardson DL, Lee S, Kimmel AR, Firtel RA. Ex- pression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium. Proc Natl Acad Sci USA 1994; 91(22): 10561-5.
  • 6Van ES, Virdy K J, Pitt GS, Meima M, Sands TW, Dereotes PN, et al. Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores. J Biol Chem 1996; 271 (39): 23623-5.
  • 7Mann SK, Yonemoto WM, Taylor SS, Firtel RA. DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase. ProcNatl Acad Sci USA 1992; 89(22): 10701-5.
  • 8Somon MN, Drisoll D, Mutzel R, Part D, Williams J, V&on M. Overproduction of the regulatory subunit of the cAMP-dependent protein kinase blocks the differentiation of Dictyostelium discoi- deum. EMBO J 1989; 8(7): 2039-43.
  • 9Ratner D, Borth W. Comparison of differentiating Dictyostelium discoideum cell types separated by an improved method of den- sity radient centrifugation. Exp Cell Res 1983; 143(1): 1-13.
  • 10Alvarez-Curto E, Saran S, Meima M, Zobel J, Scott C, Schaap P. cAMP production by adenylyl cyclase G induces prespore dif- ferentiation in Dictyostelium slugs. Development 2007; 134(5): 959-66.

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