腹膜透析患者瘦素水平与营养状况的关系

An analysis for the relationship between Leptin and the nutrition status in peritoneal dialysis patients

目的了解腹膜透析(CAPD)患者血清瘦素、炎症因子与营养状况的关系。方法以30例CAPD患者和30例健康者为研究对象,采用ELISA法测血清瘦素水平,同时检测C反应蛋白(CRP)、IL-6、TNF-α、胰岛素、白蛋白(Alb)水平,并用营养评估法(SGA)评估营养状况。结果(1)CAPD患者血清瘦素和胰岛素水平明显高于正常人(P<0.01)。(2)CAPD患者血清CRP、IL-6和TNFα-水平明显高于正常人(P<0.01)。(3)CAPD患者的营养状况较正常人差,Alb水平明显低于正常人(P<0.01)。(4)CAPD患者血清瘦素和胰岛素水平间均呈明显正相关(P<0.01),炎症因子与Alb之间均呈显著负相关(P<0.01)。炎症因子之间呈明显正相关(P<0.01)。结论CAPD患者血清瘦素、炎症因子均与营养状况关系密切。

Objective To study the relationship of serum leptin and inflammation with nutrition status in continuous ambulatory peritoneal dialysis（CAPD） patients. Methods 30 CAPD patients and 30 healthy controls were enrolled in the study. Leptin was measured by E LISA, inflammatory factors C reactive protein（CRP）, I L-6, TNF-α. These patients were classified to three nutritional categories based on SGA normalnutrition, mild-to-moderate malnutrition,and severe malnutrition. Results CAPD group had significantly higher serum leptin, peritoneal dialysis fluid leptin,insulin, CRP, IL-6 and TNF-α, lower serum Alb than the control group. IL-6 was significantly positive correlation with TNF-α. Serum leptin was no correlation with AIb,CRP, IL-6 and TNF-α. Conclusion Serum leptin and inflammation are closely related to the occurrence of malnutrition in CAPD.