羊膜腔灌注用于重度子痫前期治疗观察

The safety assessment of amniotic infusion therapy in severe preeclampsia

目的探讨重度子痫前期围生儿经超声介入羊膜腔内灌注治疗的安全性。方法对58例孕28～34周重度子痫前期的孕妇行B超介入下羊膜腔内灌注药物治疗1～2次，与对照组（37例）进行对比分析。结果治疗组行超声介入穿刺均成功，未发生羊膜腔内输液并发症，1min与5min早产儿Apgar评分均高于对照组（P〈0.01）．围生儿存活率达98．3％，呼吸窘迫综合征发生率低于对照组（P〈0．01）。结论重度子痫前期的孕妇在期待治疗中行羊膜腔内灌注术能明显降低围生儿的病死率，是一项安全、有效方法。

Objective To explore safety of severe preeclampsia by amniotic infusion therapy. Methods 58 cases with severe preeclampsia during 28 to 34 weeks pregnancy had been practised intravenous infusion as controls （37 cases）. Results Ultrasound guided amnioinfusion were all succesful in therapy group, there was no maternal complication. Statistical difference was found in premature infant apgar score between therapy group and control group. The incidence of respiratory distress syndrome was 3.4% ,whereas that of the control group was 35.1% （ P〈 0.01 ）. Conclusion Interventional ultrasonography amnioinfusion is a safe, reliable therapeatic method in severe preeclampsia. It may reduce perinatal morbidity.