ER和PR在子宫内膜癌组织表达的研究

The Expression of Estrogen And Progestogen Receptors in The Tissue of Uterine Endometrial Carcinoma

目的:利用免疫组化方法检测雌激素、孕激素受体水平在不同类型子宫内膜的表达。方法:选择子宫内膜癌55例、子宫内膜非典型增生13例及正常增殖期子宫内膜组织11例作为对照组。利用免疫组织化学方法(sp法),对以上各例标本进行雌激素及孕激素受体水平检测,并行统计学处理。结果:雌激素阳性表达在正常子宫内膜组最多,而在子宫内膜癌组对照组最少,3组比较差异有统计学意义(P<0.05)。孕激素阳性表达在正常子宫内膜组最多,在子宫内膜癌组最少,3组比较差异有统计学意义(P<0.05)。结论:雌激素是子宫内膜癌危险因素,孕激素延缓子宫内膜癌发生与发展。

Objective： To investigate the correlation of expression levels of receptors for estrogen and progestogen with the occurrence and development of uterine endothelial carcinoma. Methods. Fifty-five cases of uterine endometrial carcinoma and 13 cases of atypical hyperplasia of uterine endothelia were selected in our study. Eleven cases of normal uterine endometria were used as the control group. Immunohistochemistry was conducted to study the expression of estrogen and progestogen receptors, followed by statistical analysis of the data. Results： The estrogen receptor had the highest expression in the group of endometrial carcinoma, while the lowest one in the normal control. There were statistic differences among the three groups（P〈0.05）. The progestogen receptors were most highly expressed in normal control group, and the least expressed in endometrial carcinoma. There were also statistic differences among the three groups（P〈0.05）. Conclusion.Estrogen is one of the risk factors of uterine endometrial carcinoma. In contrary, progestogen may play an inhibitory effect on the occurrence and development of uterine endometrial carcinoma.