补肾中药对实验性骨质疏松的疗效观察及其机制探讨

Observation of Kidney—Tonifying Traditoinal Chinese Drugs Treating Experimental Osteoporosis and Exploration of Its Actions.

本实验通过卵巢切除大鼠骨质疏松模型,利用股骨矿物质含量和抗弯强度为指标观察补肾中药的疗效,并通过血清中雌二醇、睾酮和骨钙素的测定探讨其机制。实验结果发现补肾中药可以有效地防止卵巢切除大鼠的骨矿物质丢失和股骨抗弯强度的下降,但不能使已经丢失的矿物质含量和降低的抗弯强度恢复,其部分机制是通过补肾中药微弱的性激素样作用降低骨转化而抑制骨吸收,但性激素样作用可能不是主要作用。

The observation was about the effect of kidney—tonifying traditional Chinese drugs on ovariectomized rats model by measuring femur bone mineral contents, femur bending strength and further explored the drugs' actions by rneasuring the level of E_2, T and BGP in serum. The experimental results indicated that the drugs' prevented femur bone loss and bending strength decrease. But the drugs could not reverse the bone mineral content and bending strength that had reduced. The drugs partial mechanism was that it reduced bone turnover induced by inhibiting bone resorption because of its weak hormone action, but the hormone action was not the main mechanism.