微生物药物产生茵诱变育种方法的应用和进展

Application and progress of mutation breeding method of microbial drugs producing strain

产微生物药物的原始菌株往往产量较低,为满足工业生产的需要,需要通过合适的诱变育种方法进行改良。详细介绍了目前较为通用的几种物理和化学诱变育种技术及其应用情况,同时简述了获得高产突变株的几种筛选方式。

The original strains producing microbial drugs are always low. To meet the requirement of industrial production it is necessary to improve their characters by mutation breeding method. Some physical and chemical mutation breeding methods with their application were introduced in detail and some screening methods to obtain high yield mutants were reviewed .