生物过程优化的研究进展

The Study Progress in Optimization for Bioprocess

生物过程的各因素之间往往存在相互作用,对其进行优化,是一项比较复杂的工作。生物催化被认为是生物技术的第三次浪潮,生物过程优化是生物技术产业化不可缺少的一项工作,优化的目的在于提高终产物的产率和选择率。对近年来较常用的生物过程优化方法,包括非统计优化技术(单次单因子法)和统计优化技术(模式识别法、单纯形法、响应面法等)做了介绍。

Optimization for many factors of bioprocess is a complex labor, because there are comprehensive interactions among these factors. Biocatalysis is considered as the third tidal wave at biotechnology. It is necessary for bioprocess optimization in biotechnolngy industrialization aiming at increasing the rate of production and selectivity of end products. The current bioprocess optimization method were summarized, including both non - statistical technology, mono - factor method and statiscal technology, Such as pattern recognition, simplex method, response area method, etc.