欧达胃克对狗长期毒性的观察

THE OBSERVATION OF THE LONG-TERM TOXICITY ABOUT OUDAWEIKE ON DOGS

14条狗口服欧达胃克1个月,低剂量组(88.32mg·kg^(-1),相当临床量的2.2倍)与对照组比较,各项观察指标无明显差异。高剂量组(188.7mg·kg^(-1),相当临床剂量的4.7倍)用药2周后,出现较明显的胃肠反应。第4周出现肌张力障碍,测狗腓浅神经的复合动作电位有抑制表现。血液及生化检验无明显异常。组织切片镜检,可见部分狗有轻度肾浊肿和肝空泡样变。经停药10天,以上指标基本恢复。

We gave Oudaweike to fourteen dogs throuth oral administration for one month. Compared with the contrast groups, each observation index of the lower dose group(88.32 mg-kg-1 equal 2.2 times clinic dose ) had no obviously difference. The high dose group(188.7mg kg-1 equal 4.7 times clinic dose) had comparatively obvious gastrointestinal tract reaction after two weeks. They presented myodystony and complex action potential of superficial peroneal nerve inhibition.Blood and biochemical detection had no obvious abnormity.Throuth the microscopy of tissue slice, we saw parts of the dorgs had low-grade kidney enlargement and liver vacuolar degeneration. Afte ten days withdrawal, all indexes were recovery.