麻醉雄性Balb/c小鼠心功能的超声评定

Evaluation of cardiac function by echocardiography in anesthetized male Balb/c mice

目的:探讨应用超声对麻醉雄性Balb/c小鼠心功能进行评价的价值。方法:采集27只麻醉后雄性Balb/c小鼠的二维、M型、多普勒心脏超声图像,分别测量评价心脏结构和功能的各项参数。结果:所有小鼠均可获得反映心脏结构和功能的二维及M型超声心动图,约89%的小鼠能获得反映心脏血流动力学的多普勒超声心动图,统计学分析得到心脏功能正常的雄性Balb/c小鼠心脏结构和功能各项参数的参考值。结论:通过超声可以动态研究Balb/c小鼠心脏结构,准确评价小鼠心脏舒张收缩功能,为今后评价Balb/c小鼠心脏疾病模型提供定性定量指标。

Objective： To explore the value of echocardiography in cardiac anatomy and function of anesthetized male Balb/c mice. Methods： By 2D,M-mode and Doppler echocardiography 27 anesthetized Balb/c mice were collected, then all kinds of parameters were measured for assessment of cardiac anatomy and function. Results： Complete 2D and M-mode echocardiography for cardiac anatomy and function was obtained from 27 mice. Hemodynamic parameters could be recorded in 89% of the mice by Doppler echocardiography. The reference value of all parameters was obtained by statistical analysis. Conclusion： The echocardiography for assessment of cardiac anatomy and function can be consistently applied to the Balb/c mice.