矽肺患者血浆铜蓝蛋白和N─乙酰─β─D氨基葡萄糖苷酶活性的对比分析

COMPARATIVE ANALYSIS SERUM CERULOPLASMIN AND N-ACETYL-β-D-GLUCOSAMINIDASE A CTIVITY IN SILICOLIS PATIENTS

测定了矽肺患者ＳＣＰ和ＮＡＧ活性，结果表明矽肺患者的这两项生化指标均高于０期接尘对照组和正常对照组，且这两项指标之间存在正相关性；０￣＋期矽肺组ＳＣＰ和ＮＡＧ也显著高于０期接尘对照组和正常对照组。上述结果提示随着矽肺病的发展，ＳＣＰ和ＮＡＧ活性也相应地升高；ＳＣＰ和ＮＡＧ从不同的角度反映矽肺的发生和发展。但ＮＡＧ反映矽肺病变的发生，在时间上要早于ＳＣＰ。

Serum ceruloplasmin(SCP)and N-acetyl-β-D-glucosaminidase(NAG)activity were determined with the spectrophotometer.The results showed thatserum SCP and NAG activity of silicosis patients were higher than those of the Stage Ocontrol group and normal control group;There was a positive correlation between thetwo biochemical indexes.Serurn SCP and NAG activity were also significantly higher inthe Stage O￣+ silicosis group than in the Stage O control group and the normal controlgroup.It is suggested that both the SCCP;and the NAG activity increase with theexacerbation of Silicosis;So they can be used for reflection of silicosis occurrence andclinicat development,and evaluation of curative effects,but NAG reflects theoccurrence earlier than SCP.