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极重度骨髓型与肠型急性放射病的救治进展 被引量：8

The progress in treatment of severe hematopoietic and intestinal form of acute radiation syndrome
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摘要 极重度骨髓型与肠型急性放射病(ARS)一直是医学难以攻克的热点问题。本文从4个方面概括ARS治疗的新进展:①WR-2721作为细胞防护剂的机制和早期应用,可能阻断组织器官的不可逆性放射损伤;②细胞因子治疗放射病的新进展,提出重视造血恢复后患者的免疫重建; ③造血干细胞移植的适应证,骨髓间充质干细胞对放射病有重要治疗意义;④放射病的抗感染防护和治疗,临床真菌感染症状出现前,抗真菌用药的适应证。 The acute radiation syndrome（ARS）ishard to be overcome as the hot medical problem. This article presents the recent advances in the treatment： （ 1 ） The amifostin（ WR-2721 ）be mechanism and earlier periods of the cell protection to apply may interrupt organize harm. （2） New directions for therapy are stressed, using cytokines to enhance recovery of hematopoiesis and immune reconstitution. （3） The article presents guidelines for the use of hematopoietic stem cell transplantation and the mesenchymal stem cells （MSCs） have the importance treatment meaning to the ARS. （4） Indications of preemptive therapy of fungal infection in patients are described.
作者 胡锴勋 艾辉胜
机构地区 解放军
出处 《国际放射医学核医学杂志》 2006年第1期56-59,共4页 International Journal of Radiation Medicine and Nuclear Medicine
基金 国家"863"计划资助项目(2002AA216081)
关键词 辐射防护剂 细胞因子类 造血干细胞 急性放射病 Radioprotective drug Cytokine Hematopoietic stem cell Acute radiation syndrome
分类号 R818.71 [医药卫生—放射医学]
  • 相关文献

参考文献14

  • 1Komaki R,Lee JS,Milas L,et al.Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer:report of a randomized comparative trial.Int J Radiat Oncol Biol Phys,2004,58(5):1369-1377.
  • 2Galanopoulos A,Kritikou-Griva E,Gligori J,et al.Treatment of patients with myelodysplastic syndrome with amifostine.Leuk Res,2001,25(8):665-671.
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  • 4Farese AM,Casey DB,Vigneulle RM,et al.A single dose of pegylated leridistim significantly improves neutrophil recovery in sublethally irradiated rhesus macaques.Stem Cells,2001,19(6):514-521.
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  • 6Van der Meeren A,Mouthon MA,Vandamme M,et al.Combinations of cytokines promote survival of mice and limit acute radiation damage in concert with amelioration of vascular damage.Radiat Res,2004,161(5):549-559.
  • 7Drouet M,Mourcin F,Grenier N,et al.Single administration of stem cell factor,FLT-3 ligand,megakaryocyte growth and development factor,and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression:long-term followup of hematopoiesis.Blood,2004,103(3):878-885.
  • 8Streeter PR,Dudley LZ,Fleming WH.Activation of the G-CSF and Flt-3 receptors protects hematopoietic stem cells from lethal irradiation.Exp Hematol,2003,31(11):1119-1125.
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二级参考文献17

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共引文献3

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引证文献8

二级引证文献21

国际放射医学核医学杂志
2006年 第1期

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