运动性抗氧化作用对动脉硬化早期病变影响的超微结构观察

An Ultrastructural Observation on Effects of Exercise-induced Antioxidation on Early Pathogenesis of Atherosclerosis

以高脂膳食２０周诱导ＳＤ大鼠高胆固醇血症及塑造动脉粥样硬化（ＡＳ）早期病变模型。观察有氧运动对实验性高胆固醇血症大鼠血胆固醇（ＣＨＯ），脂质过氧化物（ＬＰＯ）含量和超氧化物歧化酶（ＳＯＤ）活性的影响，扫描结合透射电镜观察腹主动脉血管内膜超微结构改变。发现，高胆固醇血症伴随脂质过氧化反应增强，抗氧化酶活性降低，血管内皮细胞（ＥＣ）损伤呈ＡＳ早期改变特征。运动可明显控制高胆固醇血症，增高ＳＯＤ活性，一定程度上控制和／或减轻脂质过氧化物对ＥＣ损伤。提示，运动性抗氧化能力提高对防治ＡＳ早期病变有积极作用。

Using the experimental model of hypercholesteremia and early pathogensis of atherosclerosis (AS) in rats, We evaluated that the effect of exercise on the contents of serum cholesterol (CHO), lipid peroxides(LPO) and superoxide dismutane (SOD) activity, and the ultrastructural changes of abdominal aortic intima,using scanning (SEM) and transmission (TEM) electron microscopy. The results showed that when rats were fed on CHO-rich diet for 20 weeks, the serum CHO and LPO increased and SOD activity decreased signifi cantly. The ultrastructural features observed were characterized by the early pathogensis of AS. Neverthe less, Aerobic exercise can markedly decreased the levels of CHO and LPO with an increase of SOD activity.The injury Progressions of edothelial cells were controled to a certain degree. The present result suggested that the enhance of exercise-induced antioxidion may played a positive role in prevention and cure of early pathogenesis of AS.