直肠点滴给药治疗溃疡性结肠炎临床观察

Clinical Observation of Intra-rectal Drug Drip in the Treatment of Ulcerative Colitis

为探讨溃疡性结肠炎的有效治疗方法，对200例溃疡性结肠炎采用自制直肠点滴给药机给药治疗（观察组）．并与160例使用灌肠器的传统保留灌肠法（对照组）进行对比观察。观察组灌肠液保留6h以上182例占91％，药物完全吸收率74％，总有效率98．5％；对照组灌肠液保留6h以上70例占43．8％．药物完全吸收率31．3％，总有效率68．8％。两组对比差异有统计学意义（P〈0．01）。结果表明，以直肠给药机给药，药物保留时间长，对肠壁刺激小，易于吸收，且使用方便，可减轻医护人员劳动强度。

The objective of the study was to explore a more effective therapeutic method in the treatment of ulcerative colitis. Intra-rectal drug drip by self-designed giving-drug instrument was applied in 200 cases with ulcerative colitis （the observation group,group A）,while retention enema by enemator was applied in 160 such cases （the control group,group B）. The results of the two groups were compared. In 182 cases the enema fluid retained in the intestine for 6 hours or more,accounting for,91% （182/200）,the total drug absorption rate was 74% ,and the general effective rate was 98.5% in group A;While in 70 cases of group B, enema fluid retained for 6 hours or more,only 43.8% （70/160） ,the total drug absorption rate was 31.3%, and the general effective rate was 68. 8%. There was statistical difference （ P 〈0. 01） between both groups. It is revealed that intra-rectal drug drip by instrument is of many strong points,such as longer drug retention period,less irritation to the intestinal wall, easier absorption, simpler in use, etc.