男性吸毒人群HBV、HCV重叠感染状况及其影响因素的研究

Prevalence of HBV and HCV Co-Infection in Male Drug Addicts

目的了解男性吸毒人群中HBV、HCV重叠感染影响因素,为预防HBV、HCV提供科学依据。方法采用现况调查的方法,通过整群抽样,以问卷调查方式,随机抽取男性吸毒人员452名,收集有关资料并采集血标本452份。以ELISA方法检测血清中的HBV表面抗原与HCV抗体,用SPSS1.0进行数据统计分析。结果男性吸毒者HBV、HCV重叠感染率为29.46%,单因素分析:吸毒方式、注射频率、戒毒次数的HBV与HCV重叠感染有具有显著性差异(P<0.05),而不同职业、地区、吸毒年限、性行为等的HBV与HCV重叠感染率无显著性差异(P>0.05)。多因素分析:职业、吸毒年限、每天吸毒次数、戒毒次数、性行为是否用安全套、性伙伴是否患有肝炎、曾是否接受血液制品、接受血液制品次数等8个因素的HBV与HCV重叠感染率差异有显著性。结论男性吸毒人群是HBV与HCV感染的高危人群,并与吸毒方式、吸毒年限、性行为等因素有关。

Objective To investigate the prevalence of HBV/HCV infection among male drug addicts, and to analyze the factors associated with co-infection. To provide information for prevention and control of HBV/HCV. Methods A questionnaire survey was conducted amongst 452 male drug addicts through cluster sampling. Serum anti-HBs-Ag and anti-HCV were tested by ELISA method. Statistical analysis was performed using SPSS1.0 statistical software. Results The prevalence rate of HBV/HCV co-infection in male drug addicts was 29.46%. Results from single factor analysis showed that the HBV and HCV co-infection rates were significantly high in the drug addicts with different freak-out styles, injection frequency, or abnegate times （P〈0.05）. The co-infection rate was not correlated with the vocations, the geographic regions, drug-taking times or sexual experiences. Results from logistic analysis suggested that the presence of HBV and HCV co-infection are associated with the freak-out times, drug-taking frequency, abnegate times, vocation, condom-using, HBV infection of sexual pattern, transfusion history and number of transfusion in these addicts. Conclusion Male drug addicts are at high risk of HBV and HCV infection.