颞颌关节骨关节病发病机理与细胞因子的研究

A preliminary study on cytokines and the Pathogenesis of TMJ Osteorathrosis

颞颌关节（ＴＭＪ）骨关节病（ＯＡ）是口腔颌面外科的常见疾病，其发病机理不清，疗效不佳。作者对３６例不同程度ＴＭＪＯＡ患者关节滑液中细胞因子ＩＬ－１、ＩＬ－６活性的检测分析，从细胞及分子水平探讨ＴＭＪＯＡ的发病机理。结果表明：细胞因子ＩＬ－１、ＩＬ－６活性，随ＯＡ病变加重而升高（Ｐ＜０．０００１），且ＩＬ－１与ＩＬ－６呈正的直线相关关系（Ｐ＜０．００１）。本文从基质金属蛋白酶（ＭＭＰｓ）与其特异抑制物ＴＩＭＰｓ之间的平衡关系，以及细胞因子的调控机理等方面，探讨了ＴＭＪＯＡ的发病机理及未来的研究方向。

TMJ osteoarthrosis (OA) is frequently seen in the Oral and Maxillofacial Surgery clinics. In order to investigate cellular and molecular basis of the pathogenesis of TMJOA,the levels of IL-1 and IL-6 in synovial aspirates from different stages of TMJOA patients were determined and analysed. It was found that both of them were highly correlated with the severity of TMJOA (p<0. 0001). A positive linear correlation was also found between IL-1 and IL-6 (p <0. 0001). The balance and imbalance between MMPs and TIMPs and the modulatory mechanism of cytokines were introduced and their possible roles in the pathogenesis of TMJOA were discussed.