去甲长春花碱联合顺铂治疗晚期乳腺癌的临床疗效

Vinorelbine Combined with Cisplatin for Treatment of Patients with Advanced Breast Cancer

观察去甲长春花碱(Nayelbine,NVB)联合顺铂方案治疗晚期乳腺癌的临床疗效。运用NVB加顺铂(DDP)治疗晚期乳腺癌56例,结果总有效率达64％。主要不良反应为骨髓抑制、胃肠道反应和静脉炎。白细胞减少的发生率100％,其中Ⅲ-Ⅳ度达 45％;恶心呕吐的发生率79％,Ⅲ-Ⅳ度达25％;静脉炎的发生率38%。说明去甲长春花碱联合顺铂对经常规化疗方案复发的晚期乳腺癌疗效确切,毒性可以耐受,可以作为第二线治疗方案。

To evaluate the efficacy of combination chemotherapy with vinorelbine and cisplatin in the treatment of advanced breast cancer, fifty-six patients with advanced breast cancer were treated with combination chemotherapy of vinorelbine and cisplatin. The overall response were 64%. The main adverse drug reactions were marrow depression, vomiting and phlebitis. Dose limiting toxicity（DLT） was leukopenia and nausea with WHO grade Ⅲ～Ⅳ being in 45% and 25%. It is conclused that vinorelbine combined with cisplatin is effective and has acceptable tolerance in the patients with advanced breast cancer.