实体肿瘤血液动力学的三维数值模拟

3D Numerical simulation of hemodynamics in solid tumor

目的数值研究实体肿瘤内外三维微血管网及间质内的血液动力学。方法数值生成实体肿瘤内外三维微血管网,根据Poiseuille定律和Darcy定律分别计算微血管内压强及肿瘤组织间质压、组织液流速。结果肿瘤外部微血管内压强迅速降低,肿瘤内部微血管压强变化很小,可视为常数;肿瘤组织间质压呈现‘内高且平,外低且陡’的分布,组织液流速与之相反。结论本模型得到了较为有效的肿瘤内外三维血管网结构;血液动力学计算结果与生理实际基本吻合,为研究肿瘤内药物输运提供了可信的模型及方法。

Objective To study hemodynamics in 3D microvascular networks and interstitium of solid tumor by numedcal method. Methods Generate 3D vascular networks of solid tumor numerically; calculate intravascular pressure ,interstitial pressure and velocity by Poiseuille＇s law and Darcy＇s law, respectively. Results To vessels outside tumor, blood pressure drops rapidly, but to vessels inside tumor, it changes a little which could be assumed constant; interstitial pressure of tumor is high and plain in the center region and drops rapidly in the edge, which is reverse for interstitial fluid velocity. Conclusion An effective 3D vascular networks inside and outside of tumor was obtained; the results of hemodynamics consist with basic physiological features, and provide a credible model and method for research about drug delivery in tumor.