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花生四烯酸敏感和机械牵张门控的双孔钾离子通道TREK的研究进展 被引量:3

Recent advances in the study of arachidonic acid-sensitive and mechano-gated tandem-pore-domain potassium channels—TREK
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出处 《药学学报》 CAS CSCD 北大核心 2006年第3期193-196,共4页 Acta Pharmaceutica Sinica
基金 国家高技术研究发展计划(863计划)资助项目(2004AA2Z3815).
关键词 双孔钾离子通道 基因 花生四烯酸 tandem-pore-domain potassium channels gene arachidonic acid
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参考文献32

  • 1Lesage F, Guillemare E, Fink M, et al. TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure [J]. EMBO J, 1996,15:1004 -1011.
  • 2Rajan S, Wischmeyer E, Karschin C, et al. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels [J]. J BM Chem, 2001,276:7302-7311.
  • 3Duprat F,Lesage F, Fink M, et al. TASK, a human background K+ channel to sense external pH variations near physiological pH[J]. EMBO J, 1997,16:5464 - 5471.
  • 4Sano Y, lnamura K, Miyake A, et al. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord [ J ]. J Biol Chem, 2003,278:27406 - 27412.
  • 5Kang D, Mariash E, Kim D. Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family [ J ]. J Biol Chem, 2004 ,279 :28063 - 28070.
  • 6Magloire H, Lesage F, Couble ML, et al. Expression and localization of TREK-1 K+ channels in human odontoblasts [ J ]. J Dent Res, 2003,82:542 - 545.
  • 7Fink M, Lesage F, Duprat F, et al. A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids [ J]. EMBO J, 1998, 17: 3297 - 3308.
  • 8Maingret F, Fosset M, Lesage F, et al. TRAAK is a mammalian neuronal mechano-gated K+ channel [J]. J Biol Chem, 1999,274 : 1381 - 1387.
  • 9Bang H, Kim Y, Kim D. TREK-2, a new member of the mechano-sensitive tandem-pore K+ channel family [ J ]. J Biol Chem, 2000,275 : 17412 - 17419.
  • 10Kim D. Fatty acid-sensitive two-pore domain K+ channels [ J ]. Trends Pharmacol Sci, 2003,24:648 - 654.

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