摘要
目的观察白川胶囊短期及长期给药对大鼠心电图的影响。方法将大鼠麻醉后,记录药前标Ⅱ导联心电图,然后连续灌胃给药5 d,末次给药后,再次麻醉大鼠,分别记录药后0.5、1、2、4 h心电图;长期毒性实验中,分别于给药3个月和停药2 w测量标Ⅱ导联心电图,计算心率。结果白川胶囊0.6 g/kg在药后0.5 h对大鼠心电图R-R间期有延长作用(P<0.05);0.3 g/kg在药后4h对R电压有降低作用(P<0.05)。长期毒性实验中,用药3个月后3.01、.0 g/kg组心率显著降低,停药2 w后心率与对照组比较无显著性差异。结论白川胶囊对大鼠有可逆性抑制心率的作用。
Obiecfive： To observe the effects of Baichuan capsule on Rats＇ ECGs for short and long periOd. Memoas： we recorded anaesthetic rats＇ standard II ECGs hefore giving them drugs, then ig continuously for 5 days, and after final giving drugs, we recorded anaesthetic rats＇ ECGs again at 0.5, 1, 2, and 4h respectively; in chronic toxicity experiment, ECGs were recorded at 3 months after giving drugs and 2 weeks after no administration in order to calculate HR. Results. 0. 6g/ kg Baichuan Capsule could increase R-R interval of rats＇ ECG at 0.5h after giving drugs （P〈0. 05） and 0. 3g/kg Baichuan capsule could decrease R voltage（P〈0. 05） at 4h after giving drugs; in chronic toxicity experiment, 3.0 and 1.0 g/kg Baichuan capsule could decrease rats＇ HR at 3 months after giving drugs and at 2 weeks after no administration HR had no significant change. Conclusion： Baichuan capsule can inhibit rats＇ HR reversihlely.
出处
《湖北中医学院学报》
2006年第1期11-13,共3页
Journal of Hubei College of Traditional Chinese Medicine
基金
陕西省自然科学基金资助项目
[No2000SM41]
