α-异戊基-3,3-二甲基-2-降冰片烷甲醇中立体异构体的碳谱分析

Analysis of CMR of Stereoisomers of α-Isoamyl-3, 3-Dimethyl-2-Norbornanemetlianol

新化合物α-异戊基-3,3-二甲基-2-降冰片烷甲醇具有4对对映异构体,我们通过柱层析、^(13)C-NMR谱定量、DEPT技术、计算化学位移植等方法,确定了4对对映异构体的百分含量及各碳的化学位移。同时根据其百分含量,了解到α-异戊基-3,3-二甲基-2-降冰片烷甲醇由相应的醛与Grignard试剂合成时,应符合Cram规则。

New compound, α-isoamyl-3,3-dimethyl-2-norbornaneinethanol, is composed of four pairs of enantiomers. Percentage contents of the four pairs of enantiomers and chemical shifts of various carbons in these compounds are confirmed by seperation of column chromatograph, quantitative analysis of 13C-NMR spectra, DEPT technique and deduction of chemical shifts etc. According to percentage contents of four enantiomers, the addition reaction of the corresponding aldehyde and Grignard reagent to form α-isoamyl-3,3-dimethyl-2-norbornanemethanol is coincident with Cram rule.