儿童IgA肾病临床与病理关系的探讨

The relationship of the clinical and pathologic factors of pediatric IgA nephropathy

目的研究儿童IgA肾病的临床与病理特点。方法对2001年6月~2004年6月中国医科大学附属第二医院儿科收治的41例IgA肾病患儿进行相关的临床与病理检查,并观察其临床表现与病理的关系。结果儿童IgA肾病临床表现以血尿合并蛋白尿最多,病理改变以II^III级为主,免疫物质以IgA沉积为主,IgG、IgM也有部分沉积。病理分级越高,患儿血尿素氮和肌酐均值升高,肾小球滤过率均值下降。结论儿童IgA肾病应尽早发现,尽早治疗。应考虑到影响预后的因素,制定治疗方案,以期达到最佳疗效。

Objective To explore the clinical and pathological characteristics of pediatric IgA nephropathy. Methods We did physical and pathological examinations for 41 patients with IgA nephropathy from June, 2001 to June, 2004 in the second hospital of China Medical University and observed the relationship between them. Results The mainly clinical manifestations of pediatric IgA nephropathy were hematuria and proteinuria. The mainly pathological change was Ⅱ -Ⅲ classification. The immunologic complex included IgA, IgG, and IgM, especially IgA. The blood urea nitrogen and creatinine increased and glomerular titration rate（GFR） decreased with the higher classification of pathologic change, Conclusion Pediatric IgA nephropathy should be detected and treated early. We should make the best plan in order to maintain the normal renal function.