儿童急性荨麻疹胃镜下形态及幽门螺杆菌检测

Helicobacter pylori infection and acute urticaria with gastroduodenal tract lesions in children

目的研究急性荨麻疹胃镜下形态与病理改变的特点及其与幽门螺杆菌的关系,以提高对急性荨麻疹的认识。方法对36例急性荨麻疹住院患儿行胃镜及组织病理检查;以13C呼气试验和血抗Hp-IgG检测幽门螺杆菌感染情况,并与对照组比较。结果36例急性荨麻疹患儿中,33例胃、十二指肠黏膜不同程度受损(占91.7%),其中21例表现为十二指肠球-降交界部黏膜斑片状充血、水肿(占63.6%)。病变部位黏膜病理组织学检查均为非特异性炎症表现。病例组幽门螺杆菌感染率为16.67%,对照组为14.29%,两组差异无显著性。结论急性荨麻疹患儿大部分有胃镜下改变,且以十二指肠球-降交界部黏膜损害最多见。尽管黏膜损害表现多种多样,组织病理均为非特异性炎症表现。幽门螺杆菌感染与急性荨麻疹无明显相关性。

[Objective] Estimate the relationship between acute urticaria with gastroduodenal tract lesions in children and Helicobacter pylori（Hp） infection, and gastroscopic and histologic mucosal changes. [Methods] 36 children with acute unticaria and gastrodaodenal tract lesions were selected, gastrosecopic and histologie mucosal changes were diagnosed by gastroscope and histologic method. Hp was test by ^13C-UBT and anti-Hp-IgG in blood, and was compared with normal children. [Results] 33 children were found gastroduodenal tract lesions by gastroscope; the pathologic results were diagnosed nonspecific inflammation. The helieobaeter pylori infection rates were 16.67% in case group and 14.29% in control group. There was no significant difference between two groups. [ Conclusion] The gastroscopic and histologic mucosal changes were found in most acute urticaria with gastrodnodenal tract lesions; Moreover, there was no significant relationship between acute urticaria with gastroduodenal tract lesions and Helicobaeter pylori infection in children.