米非司酮配伍米索前列醇用于黄体期紧急避孕临床效果观察

Efficacy Assessment on Combined Mifepristone with Misoprostol for Emergent Contraception in Female Luteal Phase

目的：研究女性黄体期应用小剂量米非司酮配伍小剂量米索前列醇序贯给药法进行紧急避孕的有效性、安全性和可接受性。方法：采用前瞻性临床研究，接收符合接收标准，要求避孕，并愿意参加本课题研究的248例育龄女性，按用药时所处月经周期中黄体期的早晚，分为黄体早期（81例）、黄体中期（82例）、黄体晚期（85例）3组，所有对象空腹顿服米非司酮25mg×3片，36～48h再次同法服用米索前列醇200μg×2片，预约预期下次月经后10天内随访。观察在黄体各期用药后的妊娠率、月经的变化和副作用。结果：①248例妇女，妊娠3例，失败率1．2％；②随访时245例月经已经来湖，黄体早期组开始出血时间早于其他两组，经检验差异有显著性意义（P〈0．05）；出血持续时间3组间无显著性差异，与正常月经经期基本一致；③应用两种药物均无不良后果，副作用轻，能自行缓解。结论：小剂量米非司酮配伍小剂量米索前列醇序贯给药用于黄体期避孕是有效、安全和可行的。

Objective： To assess the efficacy, safety and feasibility on combining low dose of mifepristone with misoprestol for emergent contraception in female luteal phase. Methods： 248 women were divided into three groups according to luteal phase of the cycle. （81 cases in earlier period, 82 cases in middle period and 85 cases in later period）. All objects orally with fasting took 75mg mifepristone, then took 400μg misoprostol 36 - 48 hours later. Results： Of 248 cases, 3 women were pregnant accounting for 1.2%, 245 women had the return of menstruation. Women in earlier period group started bleeding earlier than that in other two groups （P 〈 0.05）. There was no difference in bleeding duration among three groups, which was in accord with cycle days. The main side - effect were lighter nausea and vomiting. Conclusion： It is effective, safe and feasible to combine mifepristone with misoprostol during luteal phase for emergent contraception.