慢性阻塞性肺病急性期IL－1活性变化

IL-1 from pulmonary alveolar macrophage in chromic obstructive pulmonarydisease

通过支气管肺泡灌洗术（ＥＡＬ）获取肺泡巨噬细胞（ＰＡＭ）．用大肠杆菌脂多糖（ＬＰＳ）诱导及胸腺细胞增殖反应法，检测２８例慢性阻塞性肺病（ＣＯＰＤ）患者ＰＡＭ释放白细胞介素１（ＩＬ－１）活性，并与１２例健康非吸烟者对照。结果，经ＬＰＳ刺激和未经刺激ＣＯＰＤ组的ＰＡＭ产生ＩＬ－１活性均明显高于对照组，ＣＯＰＤ组中，经ＬＰＳ刺激后ＰＡＭ产生ＩＬ－１活性，肺心病组＞肺气肿组＞慢支组。提示，ＩＬ－１在ＣＯＰＤ的发生和发展中起重要作用。

Pulmonary alveolar macrophages(PAM)were harvested with BAL technique and the activity ofIL-1 released were measured by using lipopolysaccharide stimulation and thymocyte proliferation method in28 patients with chronic obstructive pulmonary disease(COPD)and 12 healthy non-smokers selected ascontrol.The results showed that the IL-1 activity in COPD group with or without LPS stimulation weresignificantly higher than that in control.IL-1 activity in PAM of patients with cor pulmonale was signifi-cantly higher than that in patients with emphysema and chroriic brochitis(CB),IL-1 activity in patientswith emphysema was also higher than that in patients with CB. This indicates that IL-1 may play an impor-tant role in initiating and development of COPD.