新生儿重度硬肿症的甲状腺激素改变及治疗研究

ALTERATIONS OF THYROID HORMONE AND STUDY ON THE TREATMENT IN SEVERE SCLEREDEMA NEONATORUM

应用放射免疫法检测５４例重度硬肿症新生儿的血清甲状腺激素水平，发现５２例Ｔ３值（０．６２～０．９４ｎｍｏｌ／Ｌ）明显下降，２１例伴Ｔ４（６１～９１ｎｍｏｌ／Ｌ）降低，而ＴＳＨ均正常。肛温越低，硬肿面积越大者，Ｔ３值降低越明显。对２７例在常规治疗的同时，加用甲状腺片。结果表明：治疗组的体温恢复、硬肿开始消退和完全消退时间抑或血清Ｔ３、Ｔ４的上升及病死率下降均优于对照组，且无副作用，表明该药辅治本病安全有效。

oncentrations of thyroid hormone in serum were measured by using radioimmunoassay in 54 cases of severe scleredema neonatorum. Data showed that the serum leve1s of T3(0.62 0.94nmol/L)in 52 cases and T4(61 91nmol/L)in 21 cases were markedly reduced and the TSH level was normal.The lower the anal temperature and the larger the areas of the scleredema tissue were,the more markedly T3 would be reduced of 54 cases,thyroxin tablets were added simultaneously with the routine therapy in 27 cases,The results showed that the treated group was superior to the control groupin the duration of the restoration of temperature and the subsidence of scleredema tissue or the elevation of T3 and T4 in serum and the dscending of the mortality and no side effects appeared.It suggestedthat the medicine used for an adjuvant treatment should be safe and efficacious.