D,D-二龙脑酰基甲烷的合成

Synthesis of D,D-dicamphylmethane

研究了D,D-二龙脑酰基甲烷的合成方法。从天然樟脑的衍生物出发,用二异丙氨基溴化镁作为缩合反应中的碱,在温和的条件下合成了目标化合物,通过1H NMR,IR和质谱对其结构进行了表征,并对投料比、反应温度、反应时间等因素对反应收率的影响进行了考察。结果表明,最佳合成条件为:D-龙脑酸酰氯和D-龙脑甲酮及二异丙氨基溴化镁的物质的量配比为1∶1∶1.3,反应时间为4 h,反应温度为0℃,收率达64%。

A chiral fl-diketone D, D-dicamphylmethane was synthesized from natural d-camphor ramifications D-camphyl methane and D-camphyl chloride by condensation using magnesium bromide diisopropylamide as alkali under mild conditions and it was characterized by ^1H NMR, IR and element analysis. The effect of ratio of D-camphol chloride and D-camphol methane to magnesium bromide diisopropylamide, temperature and time on the yield was also investigated. Resuits showed that the optimum condensation conditions were the ratio of 1 ： 1 ： 1.3 with the reaction time 4 h at 0 ℃, and the yield came up to 64%.