微生物来源的胆固醇生物合成酶抑制剂Ⅳ．抗生素SIPI－8926－Ⅱ的研究

Enzyme inhibitor of cholesterol biosynthetic enzyme from microorganisms Ⅳ.Studies on antibiotic SIPI-8926-Ⅱ

在筛选微生物来源的胆固醇生物合成酶抑制剂过程中，应用硅胶柱层析、ＬＨ２０凝胶柱层析和重结晶等方法，从镰孢属真菌ＳＩＰＩ－８９２６菌株中。分离出具有生理活性的化合物ＳＩＰＩ－８９２６－Ⅱ。通过对其理化特性、ＵＶ、ＩＲ、ＭＳ、ＮＭＲ（￣１Ｈ和￣（１３）Ｃ）等光谱的分析，确定其结构为：７－羟基－３－（４－羟苯基）－４Ｈ－１－苯并吡喃－４－酮，与文献报道的大豆黄酮（ｄａｉｄｚｅｉｎ）结构一致。

In the course of screening for inhibitors of cholesterol biosynthetic enzyme from microbial metabolites, a physiologically active compound-SIPI-8926-Ⅱ was isolated from Fusarium fungi SIPI-8926 by solvent extraction, Silica Gel and LH20 column chromatography etc.The structure of the active compound[7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one] was elucidated to be identical with that of daidzein by means of physico-chemical properties,UV,IR,NMR(1H and￣(13)C) spectra.