过氧化脂质与家兔实验性绞窄性肠梗阻关系的研究

STUDY ON RELATIONSHIP BETWEEN LIPID PEROXIDATION AND EXPERIMENTAL STRANGULATED IN TESTINAL OBSTRUCTION IN RABBITS

作者用硫代巴比妥酸反应产物比色分析法，动态检测了３０只实验性绞窄性肠梗阻家兔和２０只实验性单纯性肠梗阻家兔的血清过氧化脂质（Ｓ－ＬＰＯ）含量，并以１０只家兔作对照，结果显示，实验性绞窄性肠梗阻家兔组的Ｓ－ＬＰＯ平均含量显著高于实验性单纯性肠梗阻家兔组和对照家兔组之值（Ｐ＜０．００１），且实验性绞窄性肠梗阻家兔的Ｓ－ＬＰＯ含量与肠绞窄时间呈直线正相关（ｒ＝０．９８３，Ｐ＜０．００１）。提示实验性绞窄性肠梗阻家兔体内脂质过氧化反应急剧增强，Ｓ－ＬＰＯ含量检测可作为诊断绞窄性肠梗阻的辅助指标之一。

Plasma lipid peroxidation was evaluated by the determination of thiobarbituric acid reaction in 3 0 rabbits with experimental strangulated intestinal obstruction(2 0 rabbits with simple obstruction and 1 0 normal ones). The results showed that the S-LPO level in the strangulation group was much higher than that in the simple pathology group and the control group (P<0.001),and the concentration of the S-LPO of strangulation group rose with the time(r=0.983,P<0. 001).The data indicated that the lipid peroxidation reaction was much more rapid in the strangulation group and the concentration of S-LPO might be used as an index of the severity of strangulation.