原发性习惯性流产的主动免疫治疗

ImmunotherapyofPrimaryHabitualAbortion

目的：探讨不同免疫次数及不同免疫原，对接受主动免疫治疗的原发性习惯性流产患者妊娠成功率的影响。方法：对３８例有习惯性流产史的接受淋巴细胞主动免疫治疗的孕妇，进行回顾性分析。结果：接受２次主动免疫治疗的患者，妊娠成功率为８７．５％（１４／１６），而接受４次免疫治疗的患者，成功率为８６．４％（１９／２２），两种疗法的成功率比较，差异无显著性。采用丈夫淋巴细胞为免疫原治疗的患者，成功率为８４．２％（１６／１９），而采用第３个体淋巴细胞为免疫原治疗的患者，成功率８９．５％（１７／１９），两组成功率比较，差异也无显著性。结论：为预防潜在的血源感染，主动免疫疗法可从４次改为２次，而免疫原可选择患者丈夫，也可采用健康的无关第３个体。

Objective:Toinvestigatewhetherdiferentnumberoftimesofimmunizationanddif-ferentimmunogenshaveanyefectontheoutcomeofpregnancyinpatientswithhistoryofprimaryhabi-tualabortion.Methods:38casesofpregnantwomenwithhistoryofprimaryhabitualabortionimmunizedwithlymphocyteswereanalysedretrospectively.Results:Theresultsshowedthatthesuccessfulpregnancyratewas87.5%(14/16)inthewomenimmunizedtwotimesandwas86.4%(19/22)inthewomenimmunizedfourtimes.Therewasnosignificantdiferencebetweenthetwogroups.Thesucessfulpregnancyratewas84.2%(16/19)inwomenimmunizedwiththeirhus-bands′lymphocytesand89.5%(17/19)inwomenimmunizedwithdonors′lymphocytes.Therewasalsonosignificantdiferencebetweenthetwogroups.Conclusions:Inordertopreventhematoge-nousinfection,activeimmunizationcouldbereducedfromfourtotwotimesandtheimmunogensmaybeselectedfromthehusbandorfromhealthydonor.