耐乐品与布比卡因用于低位硬膜外阻滞的比较

Comparison between Naropin and Bupivacaine Used in Lower Level Epidural Obstruction

目的：比较0．5％耐乐品和0．5％布比卡因对低位硬膜外麻醉的临床效果和安全性。方法：40例在硬膜外麻下施行下腹部手术的妇产科患者（ASAⅠ～Ⅱ级）随机分为二组，耐乐品组：05％耐乐品（n=20例）；布比卡因组；05％布比卡因（n=20例）。取L2～3行硬膜外穿刺，注入首次剂量耐乐品或布比卡因8～10ml。总量不超过20ml。观察两组病人用药总量、感觉阻滞范围和起效时间和副作用。结果：两组病人用药总量、感觉阻滞范围和起效时间无明显差异。耐乐品组止痛时间、肌松效果和感觉运动阻滞分离较布比卡因组强，耐乐品组低血压发生率较布必卡因高。结论：耐乐品组止痛时间、肌松效果和感觉运动阻滞分离较布比卡因组强。0．5％耐乐品比0．5％布比卡因在低位硬外麻中效果好。

Objective： To compare 0.5% Naropin with 0.5% Bupivacaine in clinical effect and safe for epidural anesthesia. Method： 40 cases of patients （ ASA Ⅰ - Ⅱ grades ） who are operated on lower abdomen under epidural anesthesia are divided into two groups; Naropin group： 0.5% Naropin （n = 20 cases）; Bupivacaine group： 0.5% Bupivacaine （n = 20 cases）. Taking L2-3 lines epidural puncture to be initially injected for Naropine or Bupivacaine 8 ～ 10 ml, gross dosage doesn＇ t exceed 20 ml. To observe two groups of patients who use gross medicine dosage, feeling obstruction scope, effect of initial taking medicine and side effect. Result： The difference between two groups using gross medicine dosage, feeling obstruction scope, effect of initial taking medicine is not clear; The Naropin group stopping pain time, muscle relaxing effect rand feeling movement obstruction separation are relatively stronger than that of Bupivacaine group ; The low blood pressure rate for Naropin is higher than that of Bupivacaine group. Conclusion： The 0.5 % Naropin is better than 0.5% Bupivacaine in low level of epidural anesthesia. The Naropin group stopping pain time, muscle relaxing effect and feeling movement obstruction separation are relatively stronger than that of Bupivacaine group.