丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征的疗效观察

Observe the Curative Effect of Livzon Bifidobacterium Preparation and Fluoxetine on Diarrehea-predominant Pattern Irritable Bowel Syndrome

目的:研究丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征(IBS)的临床疗效。方法:对54例腹泻型肠易激综合征病人随机分为治疗组30例和对照组24例,治疗组口服丽珠肠乐胶囊0.7g(2粒),每日2次,氟西汀胶囊10mg,每日2次,用8周。对照组口服丽珠肠乐胶囊0.7g,每日2次,用8周。结果:治疗组完全缓解14例(46.7%),部分缓解12例(40%),不缓解4例(13.3%),总有效率为86.7%,对照组完全缓解4例(16.7%),部分缓解11例(45.8%),不缓解9例(37.5%),总有效率为62.5%,两组有明显差异(P<0.05)。结论:丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征疗效好,副作用少,尤其适用于伴有明显心理障碍的病人。

Objective：To investigate the curative effect of livzon bifidobacterium preparation and fluoxetine on irritable bowel syndrome. Methods：54 patients with diarrehea- predominant pattern irritable bowel syndrome were enrolled in this study. The patients were divided into two groups ： 30 patients in curative group and 24 patients in control group. The patient of curative group takes livzon bifidobacterium preparation capsule 0.7g, b. i. d, and fluoxetine capsule 10mg,b. i. d. for 8 weeks. The patient of control group takes livzon bifidobacterium preparation capsule 0.7 g,b. i. d. for 8 weeks. Results： In the curative group 14 patients were complete remission（46.7% ）, 12 patients were part remission （40% ） ,4 patients were not remission （ 13. 3% ）. The total effective rate are 86.7%, In the control group 4 patients were remission（ 16.7% ）, 11 patients were part remission （45.8% ） ,9 patients were not remission（37.5% ）. The total effective rate was 62. 5 %. The two groups have significant differences （ p 〈 0.05 ）. Conclusion： The effect of Livzon bifidobacterium preparation and fluoxetine on diarrehea - predominant pattern irritable bowel syndrome is good. The two medicine have little side effect and especially for patients psychological block.