丹参与生脉对梗阻性黄疸术后肾脏功能的保护作用

THE EFFECT OF SALVIAE MILTIORRHIZAE AND SHENGMAI ON RENAL FUNCTION OF OBSTRUCTIVE JAUNDICE POST-OPERATIVE PATIENTS.

目的：探讨丹参与生脉对梗阻性黄疸术后肾脏功能保护作用.方法：将梗阻性黄疸与无黄疸的肝胆外科患者分成3组,每组各15例.黄疸对照组及无黄疸对照组术后给予一般治疗,丹参加生脉组术后1～6 d给予丹参加生脉注射液,动态观察血内毒素（LPS）,尿转铁蛋白（TFR）,尿白蛋白（ALB）和尿视黄醇（RBP）的变化.结果：丹参加生脉组术后7 d与术后1 d相比,LPS,TFR,RBP,ALB明显下降P＜0.01或＜0.05）,且低于或接近术前水平,其中ALB,RBP与黄疸对照组术后7 d相比差异有统计学意义（P＜0.05）.结论：丹参加生脉对阻塞性黄疸患者术后肾脏功能的改善有一定的临床作用.

Objective： To investigate the effect of Salviae miltiorrhizae and Shengmai on renal tunction of patients with obstructive jaundice （OJ）. Methods： This study included three groups： the OJ patients receiving SS for 6 days after operation （the SS group, n = 15）, the OJ patients not receiving SS （the OJ group, n = 15）, the patients with other hepato - biliary disorders （the Non-OJ group, n =15）. The levels of LPS, TFR, RBP, ALB were measered the day before operation and 1, 4, 7 days after operation. Results： The SS group＇s LPS, TFR, RBP, AI.B levels were cbviously lower on the 7 th day after operation compared with those on the 1st day after operation （P 〈 0.05）. Conclusion： The post- cperative use of salviae miltiorrhizae and Shengrnai for patients with obstructive jaundice may effectively decrease the postoperative levels of plasma LPS, TFR, RBP and ALB.