GSTM1及GSTT1基因多态性与宫颈癌关系的研究

THE STUDY OF THE RELATIONSHIP BETWEEN GLUTATHIONE S-TRANSFERASE M1,T1 GENOTYPES AND THE RISK OF CERVICAL CANCER.

目的：探讨GSTM1及GSTT1基因多态性与宫颈癌发生的关系.方法：采用以医院为基础的病例对照及分子流行病学研究方法,应用多重PCR技术检测125例宫颈癌病例和125例子宫肌瘤对照的GSTM1和GSTT1基因型.结果：病例组GSTM1基因纯合缺失率为58.4%,显著高于对照组43.2%（x^2=5.777,P=0.016）;GSTT1基因纯合缺失率在病例组和对照组分别为53.6%和44.0%,差别无统计学意义（x^2=2.305,P=0.129）;GSTM1和GSTT1联合缺失者患宫颈癌的危险性是两基因同时存在者的2.588倍（95%CI=1.285～5.212）.结论：GSTM1基因纯合缺失或GSTM1、GSTT1联合缺失可能与宫颈癌的发生有关.

Objective： To examine the relationship between the genetic polymorphisms of GSTM1, GSTT1 and the risk of cervical cancer. Methods： A hospital- based case- control study was conducted. 125 cases with cervical cancer and 125 controls with hysteromyoma diagnosis by pathological in Shanxi Tumor Hospital were involved in this study. The genotypes of GSTM1 and GSTT1 were detected by multi -PCR method. Results： The frequencies of GSTM1 null genotype in cases （58.4%） was signifiantly higher than that in controls （43.2%） ; The frequencies of GSTT1 null genotype in eases was 53.6%, while in controls was 4：4.0% ; The risk for cervical cancer in these with both GSTM1 null and GSTT1 null genotype was significantly higher than that in those with GSTM1 nonuull and GSTT1 nonnull genotype, with OR was 2.59. Conclusions： GSTM1 null genotype or both GSTM1 null and GSTT1 null genotye could increase the risk of cervical cancer.