西昌市吸毒人群HIV感染模式研究

STUDY ON MODE OF HIV INFECTION AMONG DRUG USERS IN XICHANG COUNTY OF SICHUAN PROVINCE.

目的：了解四川省西昌市吸毒人群吸毒方式及性行为与HIV感染的关系.方法：采用现况调查对四川省西昌市吸毒人群的社会人口学、共用注射器具静脉吸毒方式、伙伴人数和性行为情况与HIV感染的关系进行调查.同时采集血样进行HIV和梅毒抗体检测.结果：吸毒人群619人中,HIV感染率为8.6%（53/619）,其中静脉吸毒者的HIV感染率为10.1%（33/327）.在单因素分析和控制其他因素分析中,至今共用注射器具静脉吸毒的伙伴总人数与HIV感染差异均有统计学意义.趋势性检验发现随着至今共用注射器具静脉吸毒的伙伴人数的增加,吸毒人群HIV感染率也在增加.在多因素Logistic回归模型分析中,发现与HIV感染差异有统计学意义的变量是共用注射器具静脉吸毒的伙伴总人数（1～3人OR=2.47,95%CI为1.21～5.04;≥4人OR=5.13,95%CI为2.30～11.46）和彝族（OR=3.71,95%CI为2.04～6.75）.结论：吸毒人群共用注射器具静脉吸毒的社会网络大小与HIV感染有关.

Objective： To investigate patterns of sharing injection equipments and sexual behaviors associated with HIV infection anaong drug users in Xichang county of Sichuan province. Methods： During May to July, 2004, a survey was conducted to investigate socio- demographic characteristics, patterns of sharing injection equipments, number of injection equipment sharing partners, and sexual behaviors among drug users. Blood samples were also collected to detect for antibodies against HIV and syphilis. Results： Total of 619 subjects were investigated. The prevalence of HIV infection was 9.6% and 10.1% among drug uses and injection drug uses, respectively. Number of injection equipment sharing partners in the past was significant associated with HIV infection in univariate analysis and in controlled analysis, respectively. Trend analysis indicated that HIV prevalence increased along with the increase of number of injection equipment sharing partners. Multivariate logistic regression analysis showed number of injection equipment sharing partners in the past （1-3 partners, OR =2.47, 95% CI 1.21--5.04; ≥4 partners, OR = 5.13, 95% CI 2.30 -11. 46）, and Yi minority （OR = 3.71, 95 % CI 2.04 - 6.75） were independent associated with HIV infection, respectively. Conclusion： Social network of sharing injection equipment can affect HIV infection among drug users.