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5-丁酰胺基-2-(2,3-环氧丙氧基)-苯乙酮的合成 被引量：1

Synthesis of 5-butylamido-2-(2,3-epoxypropoxy) phenyl ketone
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摘要 以对丁酰胺基苯酚为原料,经酯化、Fries重排、醚化,合成了醋丁洛尔的关键中间体5-丁酰胺基-2-(2,3-环氧丙氧基)-苯乙酮,收率45.25%。在Fries重排反应中添加惰性无机盐氯化钠为助溶剂,使反应能够顺利进行。 5-Butylamido-2- （2,3-epoxypropoxy） phenyl ketone was synthesized from 4-butyramidophenol via esterification, Fries rearrangement in which sodium chloride was added as cosolvent, reacting with epoxy chloropropane, the yield was 45.25%.
作者 吕德刚 张奎 张雷
机构地区 民生药业集团绍兴医药有限公司
出处 《应用化工》 CAS CSCD 2006年第3期240-241,共2页 Applied Chemical Industry
关键词 5-丁酰胺基-2-(2 3-环氧丙氧基)-苯乙酮 醋丁洛尔盐酸盐 合成 FRIES重排 5-butylamido-2-（2,3-epoxypropoxy） phenyl ketone acetanol synthesis Fries rearrangement
分类号 TQ460.31 [化学工程—制药化工] R972.2 [医药卫生—药品]
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参考文献7

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同被引文献9

  • 1王岭,戴立言,丁军委,陈英奇.2-乙酰基-4-正丁酰胺基苯酚的合成工艺改进[J].化学反应工程与工艺,2004,20(2):178-180. 被引量：1
  • 2王晓钟,戴立言,陈英奇,王军明.醋丁洛尔的合成新工艺研究[J].高校化学工程学报,2004,18(6):729-732. 被引量：5
  • 3Cuthbert M F, Owusu A K . Effect of DL-1 -(2-acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride [Mand B17803A]a new b-adrenoceptor blocking agent,on the cardiovascularresponses to tilting and to soprenaline in man[J]. Brit J Pharmac,1971. 43:639.
  • 4BriantR H, Dollery C T, Fenyvesi T, et al. Assessment of selectiveb-adrenoceptor blockade in man[J]. Brit J Pharmac,1971, 43: 468.
  • 5BasilB,Clark J, Coffee E C J,et al. A new series of cardioselectiveadrenergic p-receptor blocking compounds . 1 -(2-acetylaminophenoxy)-3-isopropyIaminopropan-2-ols[J]. J Med Chem, 1976,19(3): 399.
  • 6WooldridgeK R H . A new cardioselective p-adrenoceptorblocking[J]. Experientia, 1972,28(12): 1404.
  • 7NasserIranpoor, Bahman Tamami, Khodabakhsh Niknam. Idoine andiodine supported on polgvinyl pyrrolidone as catalysts and reagents foralcoholysis,hydrolysis, and acetollysis of epoxides and thiiranes[J]. Can JChem, 1997, 75: 1913-1919.
  • 8NicolasP preparation of Alyaminophenols. France, Frl360165. 1964.
  • 9SurendraK, Srilakshmi Krishnaveni N, Nageswar Y V D. et al. HighlyRegioselective Ring Opening of Oxiranes with Phenoxides in the Presenceofp-Cyclodextrin in Water. J Org Chem, 2003, 68: 4994-4995.

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应用化工
2006年 第3期

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