愈合期微型种植体-骨界面的组织形态学研究

Histomorphometric characterization of osseointegration after implantation of dental mini-screw

目的研究微型种植体-骨界面在不同愈合时间下的组织形态学变化。方法应用种植钉30枚,新西兰大白兔10只。采用HE染色方法,骨磨片方法对种植体-骨界面的横纵断面进行观察。结果种植体-骨界面在愈合1、2周时界面机化,以胶原纤维包绕为主;界面在4周时表现为复合骨;愈合8周时层状骨为主,出现二次改建。结论在家兔胫骨内纯钛微种植体骨钉骨整合可在8周内完成。

Objective：To study the osseointegration after implantation of dental mini-screw under unloaded condition by histomorphometric observations. Methods：30 titanium mini-screws were used. 3 titanium implant miniscrews were implanted into each tibia of 10 New Zeland White rabbits at a distance of 10 mm between 2 mini-screws. 2 animals were sacrificed immediately, 1,2,4 and 8 weeks after operation respectively. Samples of the screws with surrounding bone tissue were examined by HE staining. Results：Progressive changes were observed in the implant-bone interface. 1 and 2 weeks after operation collagen fibers, locally absorbed areas and cancellous bones with loose connective tis- sues were found. 4 weeks after operation compact cortical bone was observed. 8 weeks after operatoin lamellar bone and second remodeling were found. Conclusion：Osseointegration between implanted mini-screw and bone tissue may complete in 8 weeks in rabbit tibia.