Prognostic factors in patients with node-negative gastric carcinoma:A comparison with node-positive gastric carcinoma

瞄准：识别淋巴的 clinicopathological 特征节点否定的胃的癌，并且另外在淋巴评估结果指示物节点否定的病人。方法：2848 个胃的癌病人，(53.5%) 1524 是淋巴节点否定。统计分析用艇长模型被执行估计结果指示物。结果：在在节点否定的淋巴和淋巴之间的再发率有有效差量节点积极的病人(14.4% 对 41.0% ， P【0.001 ) 。5 年的幸存率在比在淋巴节点积极的淋巴是显著地更低的节点否定的病人(31.1% 对 77.4% ， P【0.001 ) 。Univariate 分析表明下列因素影响了 5 年的幸存率：耐心的年龄，肿瘤尺寸，侵略的深度，肿瘤地点，起作用的类型，和在起始的诊断的肿瘤舞台。比例的危险回归建模的艇长表明那种肿瘤尺寸， serosal 侵略，和治愈可能性是独立的，淋巴的统计上重要的、预示的指示物节点否定的胃的癌。结论：淋巴节点否定的病人与相对大的肿瘤和 serosal 侵略让对高治愈可能性，而是病人可归因的有利结果有差的预后。治愈可能性是为淋巴的长期的幸存的最可靠的预言者之一节点否定的胃的癌病人。

AIM： To identify the clinicopathological characteristics of lymph node-negative gastric carcinoma, and also to evaluate outcome indicators in the lymph node-negative patients. METHODS： Of 2848 gastric carcinoma patients, 1524 （53.5%） were lymph nede-negative. A statistical analysis was performed using the Cox model to estimate outcome indicators. RESULTS： There was a significant difference in the recurrence rate between lymph nede-negative and lymph node-positive patients （14.4% vs 41.0%, P〈0.001）. The 5-year survival rate was significantly lower in lymph node-positive than in lymph node-negative patients （31.1% vs 77.4%, P〈0.001）. Univariate analysis revealed that the following factors influenced the 5-year survival rate： patient age, tumor size, depth of invasion, tumor location, operative type, and tumor stage at initial diagnosis. The Cox proportional hazard regression model revealed that tumor size, serosal invasion, and curability were independent, statistically significant, prognostic indicators of lymph node-negative gastric carcinoma. CONCLUSION： Lymph node-negative patients have a favorable outcome attributable to high curability, but the patients with relatively large tumors and serosal invasion have a poor prognosis. Curability is one of the most reliable predictors of long-term survival for lymph nodenegative gastric carcinoma patients.